Custom Peptide Synthesis

The synthesis of peptides has been a challenge to organic chemists for almost a century. Through the development of new effective techniques in synthesis, purification, and analysis within the last three decades, peptide chemistry has become a powerful tool in all fields of life sciences.

We, at piCHEM, are familiar with the most applicable and modern techniques in peptide chemistry. Depending on the structure, quantity, or special client requirements, different strategies are available, from conventional synthesis in solution to different solid phase synthesis methods. Due to this fact, we are able to provide services for custom peptide synthesis in the following topics:

 

Custom Peptide Synthesis

Synthesis, analysis, and purification of natural occurring peptides. By producing peptides from mg- to g-quantities, we are able to fulfill all our customers´ requirements. On a contract research basis, we are also able to offer the development of new routes for the peptide scale-up production up to multi-gram quantities.

 

Modifications

We have experience with synthetic methods of modifying peptides by affecting the backbone, or by incorporating unusual building blocks. We also have experience with cyclisation procedures and synthesis of lipopeptides and peptolides. Biotinylation, phosphorylation and other biological relevant modifications are also standard techniques.

 

Antigen conjugates

Our services include advice on antigenic peptide selection, synthesis, and attachment to protein-carriers by different methods for anti-peptide antibody production. Besides conventional peptide-conjugates on KLH, BSA or OVA-carriers, we also offer special products such as multiple antigenic peptides (MAPs) or PEG-attached peptide conjugates.

 

Enzyme substrates

We are able to produce a wide range of well documented chromogenic and fluorogenic enzyme-substrates on a contract manufacturing basis, as well as non-commercially available substrates for new research purposes. These items are also available in multi-gram quantities with GMP-quality.

  

Fluorescent labeled amino acid derivatives and peptides

For screening assays, we offer special fluorescent- or chromogenic-labeled amino acids. These innovative (patent pending) products are useful for the preparation of site-specific or multiple-labeled peptides for special assays like FRET- or HTS-screenings.